About the Nelson Lab

Complex Genetic Trait Analysis

The Nelson Lab uses genomic approaches towards the study of complex human diseases. We have several research programs to discover genetic variants that underly Attention Deficit and Hyperactivity Disorder, Autism, rare Mendelian disorders, and other disorders. These projects use linkage, linkage disequilibrium, association approaches and next-generation sequencing (NGS) in hundreds of affected sibling pair families. The laboratory also studies the genetic causes of glioblastoma, the most common and lethal form of primary brain cancer, using large scale gene expression analysis, alternative splicing analysis and chromosomal loss information, and is developing bioinformatic approaches to use this information to identify and prioritize novel therapeutic targets. We are also developing novel technologies based on shape encoding to allow highly multiplexed cellular and molecular assays. All of these projects require a host of integrated bioinformatics approaches which rely on a large and growing repository of gene expression information from human and mouse tissues.

Text from the Nelson Lab website: https://secure.genome.ucla.edu/index.php/Main_Page