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Functional impact of global rare copy number variation in autism spectrum disorders. PDF available through Get Fulltext Research

D, Pinto At, Pagnamenta L, Klei R, Anney D, Merico R, Regan J, Conroy Tr, Magalhaes C, Correia Bs, Abrahams ...

Published in Nature

The autism spectrum disorders (ASDs) are a group of conditions characterized by impairments in reciprocal social interaction and communication, and the presence of restricted and repetitive behaviours. Individuals with an ASD vary greatly in cognitive development, which can range from above average to intellectual disability. Although ASDs are know...

Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells. PDF available through Get Fulltext Research

Kim, Woo-Kyun Meliton, Vicente Tetradis, Sotirios Weinmaster, Gerry Hahn, Theodore J Carlson, Marc Nelson, Stanley F Parhami, Farhad

Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

We previously reported that specific oxysterols stimulate osteogenic differentiation of pluripotent bone marrow stromal cells (MSCs) through activation of hedgehog (Hh) signaling and may serve as potential future therapies for intervention in osteopenia and osteoporosis. In this study we report that the osteogenic oxysterol 20(S)-hydroxycholesterol...

Loss of CHSY1, a Secreted FRINGE Enzyme, Causes Syndromic Brachydactyly in Humans via Increased NOTCH Signaling PDF available through Get Fulltext Research

Tian, Jing Ling, Ling Shboul, Mohammad Lee, Hane O'Connor, Brian Merriman, Barry Nelson, Stanley F. Cool, Simon Ababneh, Osama H. Al-Hadidy, Azmy ...

Published in The American Journal of Human Genetics

We delineated a syndromic recessive preaxial brachydactyly with partial duplication of proximal phalanges to 16.8 Mb over 4 chromosomes. High-throughput sequencing of all 177 candidate genes detected a truncating frameshift mutation in the gene CHSY1 encoding a chondroitin synthase with a Fringe domain. CHSY1 was secreted from patients' fibroblasts...

Improving the efficiency of genomic loci capture using oligonucleotide arrays for high throughput resequencing PDF available through Get Fulltext Research

Lee, Hane O'Connor, Brian D Merriman, Barry Funari, Vincent A Homer, Nils Chen, Zugen Cohn, Daniel H Nelson, Stanley F

Published in BMC Genomics

BackgroundThe emergence of next-generation sequencing technology presents tremendous opportunities to accelerate the discovery of rare variants or mutations that underlie human genetic disorders. Although the complete sequencing of the affected individuals' genomes would be the most powerful approach to finding such variants, the cost of such effor...

BFAST: an alignment tool for large scale genome resequencing. PDF available through Get Fulltext Research

Homer, Nils Merriman, Barry Nelson, Stanley F

Published in PloS one

The new generation of massively parallel DNA sequencers, combined with the challenge of whole human genome resequencing, result in the need for rapid and accurate alignment of billions of short DNA sequence reads to a large reference genome. Speed is obviously of great importance, but equally important is maintaining alignment accuracy of short rea...

Emerging genetic therapies to treat Duchenne muscular dystrophy.

Sf, Nelson Rh, Crosbie Mc, Miceli Mj, Spencer

Published in Current Opinion in Neurology

Mutations in PYCR1 cause cutis laxa with progeroid features

Reversade, Bruno Escande-Beillard, Nathalie Dimopoulou, Aikaterini Fischer, Björn Chng, Serene C Li, Yun Shboul, Mohammad Tham, Puay-Yoke Kayserili, Hülya Al-Gazali, Lihadh ...

Published in Nature Genetics

Autosomal recessive cutis laxa (ARCL) describes a group of syndromal disorders that are often associated with a progeroid appearance, lax and wrinkled skin, osteopenia and mental retardation1,2,3. Homozygosity mapping in several kindreds with ARCL identified a candidate region on chromosome 17q25. By high-throughput sequencing of the entire candida...

Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients.

Kv, Lu S, Zhu A, Cvrljevic Tt, Huang S, Sarkaria D, Ahkavan J, Dang Eb, Dinca Sb, Plaisier I, Oderberg ...

Published in Cancer Research

Activating epidermal growth factor receptor (EGFR) mutations are common in many cancers including glioblastoma. However, clinical responses to EGFR inhibitors are infrequent and short-lived. We show that the Src family kinases (SFK) Fyn and Src are effectors of oncogenic EGFR signaling, enhancing invasion and tumor cell survival in vivo. Expression...

Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors PDF available through Get Fulltext Research

Liu, Qinghai Nguyen, David H. Dong, Qinghua Shitaku, Peter Chung, Kenneth Liu, On Ying Tso, Jonathan L. Liu, Jason Y. Konkankit, Veerauo Cloughesy, Timothy F. ...

Published in Journal of Neuro-Oncology

Glioblastoma multiforme (GBM) remains refractory to conventional therapy. CD133+ GBM cells have been recently isolated and characterized as chemo-/radio-resistant tumor-initiating cells and are hypothesized to be responsible for post-treatment recurrence. In order to explore the molecular properties of tumorigenic CD133+ GBM cells that resist treat...

Local alignment of two-base encoded DNA sequence PDF available through Get Fulltext Research

Homer, Nils Merriman, Barry Nelson, Stanley F

Published in BMC Bioinformatics

BackgroundDNA sequence comparison is based on optimal local alignment of two sequences using a similarity score. However, some new DNA sequencing technologies do not directly measure the base sequence, but rather an encoded form, such as the two-base encoding considered here. In order to compare such data to a reference sequence, the data must be d...

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