Improved variant discovery through local re-alignment of short-read next-generation sequencing data using SRMA
Published in Genome Biology
A primary component of next-generation sequencing analysis is to align short reads to a reference genome, with each read aligned independently. However, reads that observe the same non-reference DNA sequence are highly correlated and can be used to better model the true variation in the target genome. A novel short-read micro re-aligner, SRMA, that...
