Search on Nelson Lab - UCLA's publications

Phenotype sequencing: identifying the genes that cause a phenotype directly from pooled sequencing of independent mutant...

Harper, Marc A Chen, Zugen Toy, Traci Machado, Iara M P Nelson, Stanley F Liao, James C Lee, Christopher J

Published in PloS one

Random mutagenesis and phenotype screening provide a powerful method for dissecting microbial functions, but their results can be laborious to analyze experimentally. Each mutant strain may contain 50-100 random mutations, necessitating extensive functional experiments to determine which one causes the selected phenotype. To solve this problem, we ...

BFAST: an alignment tool for large scale genome resequencing.

Homer, Nils Merriman, Barry Nelson, Stanley F

Published in PloS one

The new generation of massively parallel DNA sequencers, combined with the challenge of whole human genome resequencing, result in the need for rapid and accurate alignment of billions of short DNA sequence reads to a large reference genome. Speed is obviously of great importance, but equally important is maintaining alignment accuracy of short rea...

Publication search

Phenotype sequencing: identifying the genes that cause a phenotype directly from pooled sequencing of independent mutant...

BFAST: an alignment tool for large scale genome resequencing.