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High throughput screening for compounds that alter muscle cell glycosylation identifies new role for N-glycans in regula... PDF available through Get Fulltext Research

Cabrera, Paula V Pang, Mabel Marshall, Jamie L Kung, Raymond Nelson, Stanley F Stalnaker, Stephanie H Wells, Lance Crosbie-Watson, Rachelle H Baum, Linda G

Published in The Journal of biological chemistry

Duchenne muscular dystrophy is an X-linked disorder characterized by loss of dystrophin, a cytoskeletal protein that connects the actin cytoskeleton in skeletal muscle cells to extracellular matrix. Dystrophin binds to the cytoplasmic domain of the transmembrane glycoprotein β-dystroglycan (β-DG), which associates with cell surface α-dystroglycan (...

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